Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates
JW Marsh, KA Shutt, R Pajon, MM Tulenko, S Liu… - Vaccine, 2011 - Elsevier
Several meningococcal vaccines under development for prevention of serogroup B disease
target the factor H-binding protein (FHbp), an immunogenic lipoprotein expressed on the …
target the factor H-binding protein (FHbp), an immunogenic lipoprotein expressed on the …
Genetic Diversity and Levels of Expression of Factor H Binding Protein among Carriage Isolates of Neisseria meningitidis
L Lemee, E Hong, M Etienne, AE Deghmane… - PloS one, 2014 - journals.plos.org
The prevention of meningococcal disease may be improved by recombinant vaccines such
as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic …
as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic …
Gene variability and degree of expression of vaccine candidate factor H binding protein in clinical isolates of Neisseria meningitidis
A Kelly, S Jacobsson, S Hussain, P Olcén, P Mölling - Apmis, 2013 - Wiley Online Library
The factor H binding protein (fHbp) is currently being evaluated in clinical trials as a vaccine
candidate for a meningococcal group B vaccine. We have previously described the …
candidate for a meningococcal group B vaccine. We have previously described the …
Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South Africa
KM Mothibeli, M Du Plessis, A Von Gottberg, E Murphy… - Vaccine, 2011 - Elsevier
Factor H binding protein (fHBP) is currently under investigation as a potential vaccine
antigen for protection against meningococcal serogroup B (MenB) disease. This study …
antigen for protection against meningococcal serogroup B (MenB) disease. This study …
Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in Epidemiologically Relevant Strains of Serogroup B Neisseria meningitidis
E Murphy, L Andrew, KL Lee, DA Dilts… - Journal of Infectious …, 2009 - academic.oup.com
Abstract Background Recombinant forms of Neisseria meningitidis human factor H binding
protein (fHBP) are undergoing clinical trials in candidate vaccines against invasive …
protein (fHBP) are undergoing clinical trials in candidate vaccines against invasive …
Preclinical evidence for the potential of a bivalent fHBP vaccine to prevent Neisseria meningitidis Serogroup C Disease
SL Harris, D Zhu, E Murphy, LK McNeil, X Wang… - Human …, 2011 - Taylor & Francis
A bivalent factor H binding protein (fHBP) vaccine for the prevention of disease caused by
Neisseria meningitidis serogroup B is currently in clinical development. Since fHBP is also …
Neisseria meningitidis serogroup B is currently in clinical development. Since fHBP is also …
Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
M Biagini, M Spinsanti, G De Angelis… - Proceedings of the …, 2016 - National Acad Sciences
Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the
survival of the bacterium in human blood and a component of two recently licensed vaccines …
survival of the bacterium in human blood and a component of two recently licensed vaccines …
Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a …
PT Beernink, JA Welsch, LH Harrison… - The Journal of …, 2007 - academic.oup.com
Background. Two promising recombinant meningococcal protein vaccines are in
development. One contains factor H-binding protein (fHBP) variants (v.) 1 and 2, whereas …
development. One contains factor H-binding protein (fHBP) variants (v.) 1 and 2, whereas …
Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development
R Pajon, AM Fergus, O Koeberling… - PLoS neglected …, 2011 - journals.plos.org
Background Factor H binding protein (fHbp) is an important antigen for vaccines against
meningococcal serogroup B disease. The protein binds human factor H (fH), which enables …
meningococcal serogroup B disease. The protein binds human factor H (fH), which enables …
Variation of the factor H-binding protein of Neisseria meningitidis
There is currently no comprehensive meningococcal vaccine, due to difficulties in
immunizing against organisms expressing serogroup B capsules. To address this problem …
immunizing against organisms expressing serogroup B capsules. To address this problem …