Ribosomes, the large RNPs that translate mRNA into protein in the cytoplasm of eukaryotic
cells, are synthesized in a subcompartment of the nucleus, the nucleolus. There …

Pre-rRNA synthesis and processing are key steps in ribosome biogenesis. Although recent
evidence in yeast suggests that these two processes are coupled, the nature of their …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

One of the most important tasks of any cell is to synthesize ribosomes. In eukaryotes, this
process occurs sequentially in the nucleolus, the nucleoplasm and the cytoplasm. It involves …

Most, if not all RNAs, are transcribed as precursors that require processing to gain
functionality. Ribosomal RNAs (rRNA) from all organisms undergo both exo‐and …

In eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans‐acting factors
contribute to ribosome biogenesis. After more than 30 years of intense research, the …

Ribosome biogenesis centres both physically and functionally on the activity of the
ribosomal RNA (rRNA) genes. Ribosome assembly occurs co-transcriptionally on these …

Concurrent with transcription, the ribosomal RNA precursor (pre-rRNA) is modified and
associates with many of the ribosomal proteins. The modifications are guided by small …

Ribosomal RNAs are produced as lengthy polycistronic precursors containing coding and
non-coding sequences, implying that extensive pre-rRNA processing is necessary for the …

Regulation of ribosome biogenesis is a key element of cell biology, not only because
ribosomes are directly required for growth, but also because ribosome production …