Analysis of mitochondrial respiratory chain supercomplexes using blue native polyacrylamide gel electrophoresis (BN‐PAGE)

P Jha, X Wang, J Auwerx - Current protocols in mouse biology, 2016 - Wiley Online Library
Mitochondria are cellular organelles that harvest energy in the form of ATP through a
process termed oxidative phosphorylation (OXPHOS), which occurs via the protein …

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

S Javadov, S Jang, XR Chapa-Dubocq… - Journal of Molecular …, 2021 - Springer
Mitochondria are recognized as the main source of ATP to meet the energy demands of the
cell. ATP production occurs by oxidative phosphorylation when electrons are transported …

The assembly, regulation and function of the mitochondrial respiratory chain

I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Mitochondrial respiratory chain supercomplexes: from structure to function

S Guan, L Zhao, R Peng - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondrial oxidative phospho rylation, the center of cellular metabolism, is pivotal for the
energy production in eukaryotes. Mitochondrial oxidative phosphorylation relies on the …

Respiratory supercomplexes: structure, function and assembly

R Vartak, CAM Porras, Y Bai - Protein & cell, 2013 - academic.oup.com
The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for
ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused …

Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation

G Lenaz, ML Genova - … : nuclear-encoded genes, enzyme regulation, and …, 2012 - Springer
Recent experimental evidence has replaced the random diffusion model of electron transfer
with a model of supramolecular organisation based on specific interactions between …

Sealing the mitochondrial respirasome

DR Winge - Molecular and cellular biology, 2012 - Am Soc Microbiol
The mitochondrial respiratory chain is organized within an array of supercomplexes that
function to minimize the generation of reactive oxygen species (ROS) during electron …

Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain

M Trouillard, B Meunier… - Proceedings of the …, 2011 - National Acad Sciences
Mitochondria are the powerhouses of eukaryotic cells as they feed metabolism with its major
substrate. Oxidative-phosphorylation relies on the generation, by an electron/proton transfer …

Supramolecular structure of the mitochondrial oxidative phosphorylation system

EJ Boekema, HP Braun - Journal of Biological Chemistry, 2007 - ASBMB
The protein complexes of the mitochondrial oxidative phosphorylation system were recently
reported to form supramolecular assemblies termed respiratory supercomplexes or …

Open questions: respiratory chain supercomplexes—why are they there and what do they do?

J Hirst - BMC biology, 2018 - Springer
Open questions: respiratory chain supercomplexes—why are they there and what do they do?
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