Recent reports have suggested that production of superoxide or other reactive oxygen
species by activated osteoclasts may play a role in the complex process of bone resorption; …

Production of superoxide radicals by osteoclasts is necessary for normal bone degradation.
White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH …

Superoxide production contributes to osteoclastic bone resorption. Evidence strongly
indicates that NADPH oxidase is an enzyme system responsible for superoxide generation …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Osteoclasts use a variety of chemical agents to degrade bone. One important component of
this process is the generation of superoxide. It has been reported that nicotinamide adenine …

Oxygen derived free radicals are generated by osteoclasts. In a novel culture system,
isolated rat osteoclasts were stained when nitroblue tetrazolium (NBT) was reduced by …

A new superoxide‐generating enzyme, NADPH oxidase 4 (Nox4), contributes to osteoclastic
superoxide production. In this study, we demonstrated that Nox4 is expressed at a higher …

Osteoclasts have been shown to destroy calcified tissue by complex developmental steps
involving cell recruitment, cell attachment and deployment of multiple enzymes. They also …

The reaction of superoxide with nitroblue tetrazolium produces an electron-dense
diformazan precipitate which can be used to localize areas of superoxide production …

Porcine articular chondrocytes have the capacity to release superoxide in response to the
addition of the calcium ionophore ionomycin in a concentration-dependent manner. This …