Several intracellular pathogens have developed diverse strategies to avoid targeting to
lysosomes. However, they universally recruit lysosome-associated membrane protein 1 …

Salmonella is an intracellular bacterial pathogen that replicates within a membrane-bound
vacuole in host cells. The major lysosomal membrane proteins 1 and 2 (LAMP-1 and LAMP …

Lysosomes are cellular organelles containing diverse classes of catabolic enzymes that are
implicated in diverse cellular processes including phagocytosis, autophagy, lipid transport …

Phagocytosis is a process by which invading organisms are taken up by macrophages and
targeted to the lysosomes, where they are degraded. However, many pathogens modulate …

The host endolysosomal compartment is often manipulated by intracellular bacterial
pathogens. Salmonella (Salmonella enterica serovar Typhimurium) secrete numerous …

SipA is a major effector of Salmonella, which causes gastroenteritis and enteric fever.
Caspase-3 cleaves SipA into two domains: the C-terminal domain regulates actin …

Many intracellular pathogens have evolved highly specialized mechanisms to isolate
themselves from the host cell's innate immune response while still obtaining the necessary …

Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-
bound vacuoles through the action of effector proteins translocated into host cells …

Unlike other Salmonellae, the intracellular bacterial human pathogen Salmonella Typhi
exhibits strict host specificity. The molecular bases for this restriction are unknown. Here we …

Salmonella Typhimurium is an intracellular pathogen that causes gastroenteritis in humans.
Aided by a battery of effector proteins, S. Typhimurium resides intracellularly in a specialized …