MART-1–specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic …
Y Li, S Liu, J Hernandez, L Vence, P Hwu… - The journal of …, 2010 - journals.aai.org
We determined how CD8+ melanoma tumor–infiltrating lymphocytes (TILs) isolated from two
distinct phases of expansion in preparation for adoptive T cell therapy respond to melanoma …
distinct phases of expansion in preparation for adoptive T cell therapy respond to melanoma …
Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma
E Huarte, J Fisher, MJ Turk, D Mellinger, C Foster… - Cancer letters, 2009 - Elsevier
Although T Central Memory cells have been described as the most effective T-cell subtype
against tumor growth, little is known about the requirements needed for their optimal ex vivo …
against tumor growth, little is known about the requirements needed for their optimal ex vivo …
Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy
Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor
regression in up to 50% or more of patients with unresectable metastatic melanoma …
regression in up to 50% or more of patients with unresectable metastatic melanoma …
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T …
S Hervas-Stubbs, U Mancheno… - The Journal of …, 2012 - journals.aai.org
Previous mouse and human studies have demonstrated that direct IFN-α/β signaling on
naive CD8 T cells is critical to support their expansion and acquisition of effector functions. In …
naive CD8 T cells is critical to support their expansion and acquisition of effector functions. In …
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma
T Chodon, B Comin-Anduix, B Chmielowski… - Clinical Cancer …, 2014 - AACR
Purpose: It has been demonstrated that large numbers of tumor-specific T cells for adoptive
cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous …
cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous …
T-cell therapy using interleukin-21–primed cytotoxic T-cell lymphocytes combined with cytotoxic T-cell lymphocyte antigen-4 blockade results in long-term cell …
AG Chapuis, IM Roberts, JA Thompson… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Peripheral blood–derived antigen-specific cytotoxic T cells (CTLs) provide a readily
available source of effector cells that can be administered with minimal toxicity in an …
available source of effector cells that can be administered with minimal toxicity in an …
[HTML][HTML] Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice
Z Hu, J Xia, W Fan, J Wargo, YG Yang - Oncotarget, 2016 - ncbi.nlm.nih.gov
A major factor hindering the exploration of adoptive immunotherapy in preclinical settings is
the limited availability of tumor-reactive human T cells. Here we developed a humanized …
the limited availability of tumor-reactive human T cells. Here we developed a humanized …
Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
JA Chacon, AA Sarnaik, JQ Chen, C Creasy… - Clinical Cancer …, 2015 - AACR
Purpose: Cultured tumor fragments from melanoma metastases have been used for years as
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
[HTML][HTML] Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients …
C Saberian, RN Amaria, AM Najjar… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background The adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated
robust efficacy in metastatic melanoma patients. Tumor antigen–loaded dendritic cells (DCs) …
robust efficacy in metastatic melanoma patients. Tumor antigen–loaded dendritic cells (DCs) …
Enrichment of CD8+ cells from melanoma tumor-infiltrating lymphocyte cultures reveals tumor reactivity for use in adoptive cell therapy
PA Prieto, KH Durflinger, JR Wunderlich… - Journal of …, 2010 - journals.lww.com
Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic
melanoma has shown objective response rates as high as 72%. The successful application …
melanoma has shown objective response rates as high as 72%. The successful application …