Iron is an essential element for life, but its soluble form is scarce in the environment and is
rarer in the human body. Mtb (Mycobacterium tuberculosis) produces two aryl-capped …

MbtA is an adenylating enzyme from Mycobacterium tuberculosis that catalyzes the first step
in the biosynthesis of the mycobactins. A bisubstrate inhibitor of MbtA (Sal-AMS) was …

Mycobactin acylation plays a crucial role in the ability of Mycobacterium tuberculosis to
acquire intracellular iron during infection. M. tuberculosis Rv1347c, the lysine Nε …

The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this
bacterium to access iron when it is in an infected host. Due to this essential function, there is …

The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally
depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme …

To measure molecular changes underlying pathogen adaptation, we generated a
searchable dataset of more than 12,000 mass spectrometry events, corresponding to lipids …

Mycobactins are a family of membrane-associated siderophores required for Mycobacterium
tuberculosis to adapt to its intracellular habitat. These lipophilic siderophores have been …

Background: Many pathogenic bacteria secrete iron-chelating siderophores as virulence
factors in the iron-limiting environments of their vertebrate hosts to compete for ferric iron …

The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …

Iron is essential for the pathogenicity and virulence of Mycobacterium tuberculosis, which
synthesises salicyl‐capped siderophores (mycobactins) to acquire this element from the …