Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
M Biagini, M Spinsanti, G De Angelis… - Proceedings of the …, 2016 - National Acad Sciences
Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the
survival of the bacterium in human blood and a component of two recently licensed vaccines …
survival of the bacterium in human blood and a component of two recently licensed vaccines …
Meningococcal factor H binding protein as immune evasion factor and vaccine antigen
S Principato, M Pizza, R Rappuoli - FEBS letters, 2020 - Wiley Online Library
Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …
Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter
F Oriente, V Scarlato, I Delany - Journal of bacteriology, 2010 - Am Soc Microbiol
Factor H binding protein (fHBP) is a surface-exposed lipoprotein in Neisseria meningitidis,
which is a component of several investigational vaccines against serogroup B …
which is a component of several investigational vaccines against serogroup B …
Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates
JW Marsh, KA Shutt, R Pajon, MM Tulenko, S Liu… - Vaccine, 2011 - Elsevier
Several meningococcal vaccines under development for prevention of serogroup B disease
target the factor H-binding protein (FHbp), an immunogenic lipoprotein expressed on the …
target the factor H-binding protein (FHbp), an immunogenic lipoprotein expressed on the …
Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood
KY Dunphy, PT Beernink, B Brogioni… - Infection and …, 2011 - Am Soc Microbiol
Binding of the complement inhibitor factor H (fH) to the surface of Neisseria meningitidis is
critical for evasion of innate host defenses. The meningococcal vaccine candidate factor H …
critical for evasion of innate host defenses. The meningococcal vaccine candidate factor H …
Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce …
KL Seib, B Brunelli, B Brogioni, E Palumbo… - Infection and …, 2011 - Am Soc Microbiol
Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …
Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37
KL Seib, D Serruto, F Oriente, I Delany… - Infection and …, 2009 - Am Soc Microbiol
Factor H-binding protein (fHBP; GNA1870) is one of the antigens of the recombinant vaccine
against serogroup B Neisseria meningitidis, which has been developed using reverse …
against serogroup B Neisseria meningitidis, which has been developed using reverse …
Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis
M Scarselli, F Cantini, L Santini, D Veggi… - Journal of molecular …, 2009 - Elsevier
The factor H binding protein (fHbp) is a 27-kDa membrane-anchored lipoprotein of Neisseria
meningitidis that allows the survival of the bacterium in human plasma; it is also a major …
meningitidis that allows the survival of the bacterium in human plasma; it is also a major …
Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development
R Pajon, AM Fergus, O Koeberling… - PLoS neglected …, 2011 - journals.plos.org
Background Factor H binding protein (fHbp) is an important antigen for vaccines against
meningococcal serogroup B disease. The protein binds human factor H (fH), which enables …
meningococcal serogroup B disease. The protein binds human factor H (fH), which enables …
Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease
LK McNeil, RJ Zagursky, SL Lin, E Murphy… - Microbiology and …, 2013 - Am Soc Microbiol
Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …
and can cause devastating invasive disease. Although capsular polysaccharide-based …