The physical and chemical factors that allow DNA to perform its functions in the cell have
been studied for several decades. Recent advances in the synthesis and manipulation of …

Based on a series of elegant experiments, Kool and coworkers [1] concluded that not
Watson±Crick hydrogen bonding but steric effects, that is, the shape of DNA bases is mainly …

That hydrogen bonds play a central role in forming Watson–Crick (W–C) AT and GC base
pairs is a fundamental paradigm dating from the discovery of the structure of DNA in 1953. In …

The genetic alphabet is composed of two base pairs, and the development of a third,
unnatural base pair would increase the genetic and chemical potential of DNA. d 5SICS-d …

Hydrogen-bonding and stacking interactions between nucleobases are the major
noncovalent forces that stabilize the DNA and RNA double helix.[1, 2] The relative …

DNA polymerase enzymes make an error only once per 10 4–10 5 initial nucleotide
insertions during DNA replication. Most currently held models of this high fidelity cite the …

Studies of the enzymatic mechanisms responsible for DNA synthesis and mutations have
often focused on the structural and energetic issues of base pair geometry and Watson …

Until recently, the large majority of studies of the origins of DNA replication fidelity have
concluded that complementarity of hydrogen bonding is the chief source of energetic …

The noncovalent interactions affecting the thermodynamic stability of natural and modified
DNA have been topics of broad interest in recent years. The effects of sterics, stacking …

Recent experiments have presented evidence that Watson–Crick hydrogen bonds in a base
pair are not absolute requirements for efficient synthesis of that pair by DNA polymerase …