The processes responsible for primary tissue failure of bioprostheses were illustrated.
Calcification is the major cause of failure of porcine bioprosthetic valves, usually with …

Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Human Disease The development of an ideal cardiac valve substi-tute remains a major
problem in cardiac surgery. Mechanical prosthetic valves are usually durableand …

Background: Primary tissue failure, which is mainly caused by calcification, is still the limiting
factor in the long-term outcome of heart valve bioprostheses. Even though the precise nature …

Ethanehydroxydiphosphonate therapy was studied for prevention of calcification of
bioprosthetic heart valve cusps (from glutaraldehyde-preserved porcine aortic valves) …

Calcification limits the long-term success of heart valve bioprostheses fabricated from
glutaraldehyde cross-linked porcine aortic valves. The pathophysiology of calcification of …

Since calcification limits the durability of contemporary bioprosthetic heart valves,
antimineralization treatments are being widely investigated. Potential antimineralization …

Gross, histologic and ultrastructural studies were made of 14 porcine valve bioprostheses
that were found to contain calcific deposits at the time of removal either at reoperation (13 …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

Methods Four bovine pericardial and two porcine mitral valves (Baxter) with a tissue annulus
diameter (TAD) of 29 mm (one 27 mm) were investigated in parallel under identical test …