Background Both genetic and early life risk factors play important roles in the pathogenesis
and progression of adult depression. However, the interplay between these risk factors and …

Depression is the most prevalent mental disorder with substantial morbidity and mortality.
Although genome-wide association studies (GWASs) have identified multiple risk variants …

Depression is a common psychiatric disorder and a leading cause of disability worldwide.
Here we conducted a genome-wide association study meta-analysis of six datasets …

Advancing ability to predict who is likely to develop depression holds great potential in
reducing the disease burden. Here, we use the predictable and large increase in depression …

Introduction Depression is a common, though heterogenous, comorbidity in late-onset
Alzheimer's Disease (LOAD) patients. In addition, individuals with depression are at greater …

Major depression (MD) is a common mental disorder and a leading cause of disability
worldwide. We conducted a GWAS meta-analysis of more than 1.3 million individuals …

Importance Genetic studies with broad definitions of depression may not capture genetic risk
specific to major depressive disorder (MDD), raising questions about how depression …

Depression is a polygenic trait that causes extensive periods of disability and increases the
risk of suicide, a leading cause of death in young people. Previous genetic studies have …

Background Despite moderate heritability estimates for depression‐related phenotypes, few
robust genetic predictors have been identified. Potential explanations for this discrepancy …

Depression is a leading cause of worldwide disability but there remains considerable
uncertainty regarding its neural and behavioural associations. Here, using non-overlapping …