A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization.
In these experiments, the time-dependent effects of quinidine on the delayed rectifier …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

Background The antiarrhythmic action of quinidine is associated with a slowing of
conduction and prolongation of repolarization. The latter effect has no consistent correlation …

Imipramine is a tricyclic antidepressant drug that also exhibits antiarrhythmic effects and
whose clinical spectrum of activity is similar to that of quinidine. It has been previously …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

The aim of this study was to investigate the possible role of the interaction of different
potassium channels in dog ventricular muscle, by applying the conventional microelectrode …

We examined the effects of quinidine (5-20 microM) on transmembrane action potentials
and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine …

Background In the companion article, we report a significant difference in quinidine effects
on the action potential duration between surface (epicardial and endocardial) cells and …