Adequate pain sensitivity requires a delicate balance between excitation and inhibition in
the dorsal horn of the spinal cord. This balance is severely impaired in neuropathy leading …

Aberrant GABAergic inhibition in spinal dorsal horn may underlie some forms of neuropathic
pain. Potential, but yet unexplored, mechanisms include reduced excitability, abnormal …

Networks of the dorsal horn of the spinal cord process nociceptive information from the
periphery. In these networks, the excitation–inhibition balance is critical to shape this …

Neuropathic pain (NPP) due to sensory nerve injury is, in part, the result of peripheral
sensitization leading to a long-lasting increase in synaptic plasticity in the spinal dorsal horn …

Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …

Background Voltage‐gated calcium channel α2δ1 subunit is the binding site for gabapentin,
an effective drug in controlling neuropathic pain states including thermal hyperalgesia …

Endogenous pain control is, in part, mediated by descending inhibition of spinal nociception
via spinal release of noradrenaline. Antinociception by activation of descending …

Background The complex neuronal circuitry of the dorsal horn of the spinal cord is as yet
poorly understood. However, defining the circuits underlying the transmission of information …

Inflammatory diseases and neuropathic insults trigger signaling cascades, which frequently
lead to intense and long-lasting pain syndromes in affected patients. Such pain syndromes …

Dysfunction of the spinal GABAergic system has been implicated in pain syndromes
following spinal cord injury (SCI). Since lamina I is involved in nociceptive and thermal …