This review of major depressive disorder is a comprehensive account of the genetic,
biochemical, and neurophysiological changes that have been implicated in the disorder. No …

The clinical features, genetic data, psychopharmacological studies, hormonal abnormalities,
and biochemical observations all serve to define major depressive illness as an inherited …

Thousands of studies have been conducted of the functioning of the many neurotransmitter
systems in order to explore the biologic basis of major depressive disorder. Instead of …

• This is a report on the history and implications of the collaborative effort that evolved from
the 1969 National Institute of Mental Health conference on the psychobiology of depression …

Depression is a major illness. While its precise prevalence is unknown, some 400,000
patients are treated annually in the USA and suicide is rated as the tenth greatest cause of …

Over the course of a lifetime, major depressive disorder (MDD) afflicts 1 in 6 individuals in
the general United States population, 1 women twice as often as men, 2 and is the leading …

The monoamine hypothesis of depression predicts that the underlying pathophysiologic
basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

THROUGHOUT most of recorded history, literary and clinical descriptions of depression
have adhered to a rigid separation between mental processes and their physical substrates …

Copyright 1998 Scientific American, Inc. tions by intuition and trial and error, a situation that
can put suicidal patients in jeopardy for weeks or months until the right compound is …