Because apelin may play an important regulatory role in human cardiac dysfunction, we
investigated alterations in cardiovascular content of apelin and its receptor, APJ, during …

BACKGROUND: Apelin and its receptor APJ have been shown to have beneficial effects on
cardiovascular function. Apelin was shown to elicit hypotensive effects and also a positive …

Background Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The
association between apelin and cardiac modeling has been reported. However, if serum …

APJ was cloned as an orphan G protein-coupled receptor and shares a close identity with
angiotensin II type 1 receptor (AT1R). Apelin is a peptide that has recently been identified as …

Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart
failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …

Apelin, a novel multifunctional peptide implicated in the regulation of the cardiovascular
system, including blood pressure and cardiac function control, has been postulated to be …

BACKGROUND: Chronic kidney diseases lead to severe cardiovascular consequences
such as hypertension and cardiac failure. Apelin, along with its receptor APJ have been …

Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Background and purpose: The aim of this study was to determine whether the apelin/APJ
system is altered in human cardiovascular disease by investigating whether the expression …

BACKGROUND: Apelin is a novel endogenous peptide with inotropic and vasodilatory
properties that is the ligand for the APJ receptor. Apelin and APJ are widely distributed in the …