[HTML][HTML] Synergism between IGF2BP1 and ETV6-RUNX1 in the Pathogenesis of ETV6-RUNX1 Positive B-Acute Lymphoblastic Leukaemia

G Sharma, T Tran, J Bassi, AK Jaiswal, C Tso, A Jain… - Blood, 2021 - Elsevier
Acute lymphoblastic leukaemia (ALL) is the most common pediatric haematological
malignancy with a prevalence of around 85% cases of B cell origin. ETV6-RUNX1 is the …

Cooperativity of IGF2BP1 and ETV6-RUNX1 in the pathogenesis of ETV6-RUNX1 positive B-Cell Acute Lymphoblastic Leukemia

G Sharma, TM Tran, J Bassi, Y Tan, AK Jaiswal, C Tso… - 2022 - researchsquare.com
Background ETV6-RUNX1 is the most prevalent translocation in pediatric B-ALL (B-cell
Acute Lymphoblastic Leukemia). However, the exact pathogenesis of this translocation …

RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia

G Sharma, TM Tran, I Bansal, MS Beg… - Journal of Experimental …, 2023 - Springer
Background Acute lymphoblastic leukemia (ALL) is the most common pediatric
hematological malignancy, with ETV6:: RUNX1 being the most prevalent translocation …

[HTML][HTML] Role of IGF2BP1 and Target Genes in ETV6-RUNX1 Positive B-Acute Lymphoblastic Leukemia

JK Palanichamy, G Sharma, T Nidhi, A Chopra… - Blood, 2019 - Elsevier
Acute Lymphoblastic Leukemia is the most prevalent hematological neoplasm in Indian
children and around 85% are of B-cell origin (B-Acute Lymphoblastic Leukemia (B-ALL)) …

ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t (12; 21)(p13; q22)-positive acute lymphoblastic leukemia

M Stoskus, G Vaitkeviciene, A Eidukaite… - Blood Cells, Molecules …, 2016 - Elsevier
The oncofetal RNA-binding protein IGF2BP1 (IGF2 mRNA binding protein 1) is
overexpressed in a subset of cancers and promotes cell cycle, migration and aggressive …

Diagnostic Utility of IGF2BP1 and its targets as potential biomarkers in ETV6-RUNX1 positive B-cell acute lymphoblastic leukemia

G Sharma, E Boby, T Nidhi, A Jain, J Singh… - Frontiers in …, 2021 - frontiersin.org
Around 85% of childhood Acute Lymphoblastic Leukemia (ALL) are of B-cell origin and
characterized by the presence of different translocations including BCR-ABL1, ETV6 …

Long-term follow-up of ETV6–RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor

A Enshaei, CJ Schwab, ZJ Konn, CD Mitchell… - Leukemia, 2013 - nature.com
The ETV6–RUNX1 fusion gene is present in 25% of children diagnosed with B-cell
precursor acute lymphoblastic leukaemia (BCP-ALL) and is associated with an excellent …

Rare concomitance of ETV6:: RUNX1 and BCR:: ABL1p210 in a child diagnosed with B-cell precursor acute lymphoblastic leukemia

TC Barbosa, E Oliveira, CB Blunck, ALT Maciel… - Cancer Genetics, 2023 - Elsevier
Results Immunophenotypic analysis showed three distinct blast populations in the BM and
this was monitored during the progression of the disease, which revealed the complexity of …

ETV6-RUNX1 Rearrangement in Tunisian Pediatric B‐Lineage Acute Lymphoblastic Leukemia

A Gmidene, H Elghezal, H Sennana… - Advances in …, 2009 - Wiley Online Library
In this study, Forty‐one out of fifty‐seven Tunisian children with B‐lineage acute
lymphoblastic leukemia (B‐ALL), and without cytogenetically detectable recurrent …

[HTML][HTML] Targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia

R Polak, MB Bierings, CS van der Leije… - Blood, 2014 - Elsevier
Abstract Background: Translocation t (12; 21), resulting in the ETV6-RUNX1 fusion protein,
is present in 25% of pediatric patients with B-cell precursor acute lymphoblastic leukemia …