Acute painful crisis is a common sequela that can cause significant morbidity and negatively
impact the quality of life of patients with sickle cell disease (SCD). Plasma levels of several …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Thirty-three subjects with sickle cell disease (SCD), 11 during episodes of pain and 22
during periods without pain, were evaluated for in vivo thrombogenic activities as compared …

Background The contribution of hypercoagulability to the pathophysiology of sickle cell
disease (SCD) remains poorly defined. We sought to evaluate the association of markers of …

Sickle cell disease has been described by many scholars as a chronic inflammatory disease
which is linked to many factors such as endothelial destruction, increased synthesis of …

Sickle Cell Anemia (SCA) is the most common genetic disorder around the world. The
mutation in the β-globin gene is responsible for a higher hemolysis rate, with further …

BACKGROUND: The pathophysiology of sickle cell disease (SCD) is complex, with
increasing evidence of a pronounced prothrombotic state. OBJECTIVE: We investigated …

Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin
generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic …