Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the
morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic …

Efflux, particularly that mediated by the resistance-nodulation-division (RND) family of
multiple antibiotic efflux systems that are prevalent in Gram-negative pathogenic bacteria, is …

The discovery of antibiotics represented a key milestone in the history of medicine. However,
with the rise of these life-saving drugs came the awareness that bacteria deploy defense …

The rise in multidrug resistance (MDR) is one of the greatest threats to human health
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …

The emergence of active efflux as a major causative factor in antibiotic resistance has been
one of the most significant trends in antiinfective chemotherapy over the last decade. The …

Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae
and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat …

Resistance-Nodulation-Division (RND) efflux pumps are one of the most important
determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever …

Infectious diseases remain one of the principal causes of morbidity and mortality in the
world. Relevant authorities including the WHO and CDC have expressed serious concern …

Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …