Living with Sjӧgren's disease (SjD), or Sjӧgren's syndrome or simply Sjӧgren's, is mostly
about learning to cope with physical tiredness, dryness, and joint pain. It is predominantly …

Introduction Sjögren's Disease, SjD, is a systemic autoimmune disorder characterized by
reduced function of the salivary and lacrimal glands. Patients suffer from dryness, fatigue …

Among all the chronic autoimmune rheumatic disorders, Sjogren's disease (SD) is among
the most difficult to evaluate and manage. Clinicians are frequently challenged to …

Introduction Blisibimod is a potent B cell-activating factor (BAFF) antagonist that binds to
both cell membrane-expressed and soluble BAFF. The goal of these first-in-human studies …

B-cell activating factor (BAFF), a member of the family of TNF-like cytokines, supports the
survival and differentiation of B cells. The successful development of belimumab, a human …

Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by
a triad of symptoms that affect all patients (dryness, pain and fatigue). In addition, systemic …

The theme of the 14th International Sjögren's Symposium (ISSS) held in Washington DC,
between the 18th and the 21st of April, 2018 was “Paths to Precision Diagnosis and …

Just over 15 years ago, 2 independent investigative groups reported the B cell agonist
properties of a newly identified member of the tumor necrosis factor (TNF) ligand …

Introduction Despite ongoing efforts to develop effective therapeutics, no disease-modifying
drugs have been officially licensed for the indication of Sjögren's disease (SjD). This is partly …

Recently, the B cell has emerged as a cornerstone of systemic lupus erythematosus (SLE)
pathogenesis. This has been highlighted by studies of the cytokine B‐cell‐activating factor of …