Pan-sarbecovirus neutralizing antibodies in BNT162b2-immunized SARS-CoV-1 survivors

CW Tan, WN Chia, BE Young, F Zhu… - … England Journal of …, 2021 - Mass Medical Soc
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of
concern pose a challenge to the effectiveness of current vaccines. A vaccine that could …

Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine

Y Feng, M Yuan, JM Powers, M Hu, JE Munt… - Science translational …, 2023 - science.org
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants that evade immunity elicited by vaccination has placed an imperative on the …

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

W He, R Musharrafieh, G Song, K Dueker, LV Tse… - Nature …, 2022 - nature.com
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …

Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

WN Chia, CW Tan, AWK Tan, B Young, TN Starr… - Science …, 2023 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates

Z Liu, J Zhou, X Wang, W Xu, Z Teng… - Proceedings of the …, 2023 - National Acad Sciences
The recently emerged Omicron subvariants XBB and BQ. 1.1 have presented striking
immune evasion against most monoclonal neutralizing antibodies and convalescent …

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

DR Martinez, A Schäfer, S Gobeil, D Li… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Y Wang, M Liu, Y Shen, Y Ma, X Li, Y Zhang, M Liu… - Cell discovery, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
of concern, including Alpha (B. 1.1. 7), Beta (B. 1.351), Gamma (P. 1), Delta (B. 1.617. 2) …

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

CA Jette, AA Cohen, PNP Gnanapragasam… - Cell reports, 2021 - cell.com
Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing
antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike …

Broad neutralization of SARS-related viruses by human monoclonal antibodies

AZ Wec, D Wrapp, AS Herbert, DP Maurer… - Science, 2020 - science.org
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs)
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Z Liu, J Zhou, W Xu, W Deng, Y Wang, M Wang… - Cell research, 2022 - nature.com
The emergence of SARS-CoV-2 variants and potentially other highly pathogenic
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …