The acute and chronic effects of amiodarone were studied on the transmembrane ionic
currents in rabbit single ventricular myocytes at 35 degrees C by applying the whole-cell …

Ca current (l) block by amiodarone and the underlying mechanisms thereof were
investigated in guinea pig single ventricular myocytes using the single suction pipette whole …

This article reviews experimental studies on the electrophysiological effects of amiodarone
on mammalian hearts. Acute application of amiodarone (0.1-10ƒÊM) to papillary muscles or …

Acute effects of amiodarone on cardiac sodium channels were investigated in ventricular
myocytes isolated from guinea-pig hearts, and compared with those of lignocaine. 2 …

1. Single myocytes were isolated from the rabbit atrioventricular node (AVN) and whole cell
patch clamped, using a Cs+-based internal dialysis solution. Depolarizing voltage clamps …

Amiodarone therapy leads to a significant impairment in myocardial conduction, yet it
causes only a modest decrease in the maximum rate of depolarization of the action potential …

Amiodarone is an effective antiarrhythmic drug handicapped by serious side effects. The
mechanism of its antiarrhythmic activity is not known but is presumed to involve inhibition of …

The effects of long-term administration of oral amiodarone on transmembrane action
potential and contraction of ventricular muscle were investigated in rabbits. 2. ECGs of …

Sodium current (INa) block by amiodarone (AMI) was investigated in isolated single Purkinje
and ventricular myocardial cells using the single suction-pipette voltage-clamp technique …

We studied the electrophysiological effects of amiodarone on isolated rabbit heart muscles
by conventional microelectrode techniques. It significantly suppressed not only sinus node …