Bacterial efflux transporters' polyspecificity–a gift and a curse?
Highlights•Polyspecificity of bacterial RND efflux pumps is the key to environmental
versatility and antibiotic resistance of Gram-negative bacteria.•Synergy with the outer …
versatility and antibiotic resistance of Gram-negative bacteria.•Synergy with the outer …
Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance
The discovery of bacterial efflux pumps significantly advanced our understanding of how
bacteria can resist cytotoxic compounds that they encounter. Within the structurally and …
bacteria can resist cytotoxic compounds that they encounter. Within the structurally and …
Waltzing transporters and'the dance macabre'between humans and bacteria
O Lomovskaya, HI Zgurskaya, M Totrov… - Nature reviews Drug …, 2007 - nature.com
Multidrug-resistance efflux pumps—in particular those belonging to the resistance-
nodulation-cell-division (RND) family of transporters, with their unusually high degree of …
nodulation-cell-division (RND) family of transporters, with their unusually high degree of …
Bad bugs in the XXIst century: resistance mediated by multi-drug efflux pumps in Gram-negative bacteria
The discovery of antibiotics represented a key milestone in the history of medicine. However,
with the rise of these life-saving drugs came the awareness that bacteria deploy defense …
with the rise of these life-saving drugs came the awareness that bacteria deploy defense …
Structural and functional diversity of resistance–nodulation–cell division transporters
Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …
becoming increasingly difficult to eliminate. While significant effort has gone into the …
Efflux in Gram-negative bacteria: what are the latest opportunities for drug discovery?
Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …
RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance
AL Colclough, I Alav, EE Whittle, HL Pugh… - Future …, 2020 - Taylor & Francis
Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …
Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa
S Yamasaki, M Zwama, T Yoneda… - …, 2023 - microbiologyresearch.org
Drug efflux pumps transport antimicrobial agents out of bacteria, thereby reducing the
intracellular antimicrobial concentration, which is associated with intrinsic and acquired …
intracellular antimicrobial concentration, which is associated with intrinsic and acquired …
Making sense of drug-efflux transporters in the physiological environment
Highlights•RND pumps of P. aeruginosa and A. baumannii, fall into three different
categories.•The three categories of efflux pumps participate in different physiological …
categories.•The three categories of efflux pumps participate in different physiological …
Ever-adapting RND efflux pumps in gram-negative multidrug-resistant pathogens: a race against time
The rise in multidrug resistance (MDR) is one of the greatest threats to human health
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …