Despite distinct advantages over mechanical cardiac valve prostheses, the use of
bioprosthetic valves remains limited, due to poor long-term durability, primarily as a result of …

Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Despite distinct advantages over mechanical cardiac valve prostheses, the use of
bioprosthetic valves remains limited due to poor long-term durability, primarily as a result of …

Attempts to replace diseased human valves with prostheses began more than 30 yrs ago.
Heart valve prostheses can be broadly classified into mechanical prostheses (made out of …

Natural and bioprosthetic heart valves suffer from calcification, despite their differences in
etiology and tissue material. The mechanism of developing calcific deposits in valve tissue is …

The importance of glutaraldehyde pretreated bioprosthetic heart valves fabricated from
bovine pericardium or porcine aortic valves is well realized in the management of valvular …

Since calcification limits the durability of contemporary bioprosthetic heart valves,
antimineralization treatments are being widely investigated. Potential antimineralization …

Intrinsic tissue calcification mainly results from increased penetration of plasma proteins into
the leaflets of bioprosthetic cardiac valves. The loss of activity of natural calcification …

The purpose of this study was to characterize the physicochemical properties of calcific
deposits that cause the failure of tissue‐derived heart valve bioprostheses. This was done in …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …