[PDF][PDF] Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing

LA Boursinos, T Karachalios, L Poultsides… - J Musculoskelet …, 2009 - ismni.org
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs
worldwide. They are prescribed for orthopaedic conditions such as osteoarthritis, soft-tissue …

Effect of non-steroidal anti-inflammatory drugs on bone healing

J Cottrell, JP O'Connor - Pharmaceuticals, 2010 - mdpi.com
Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by
inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation …

Is there an inhibitory effect of COX-2 inhibitors on bone healing?

AB Seidenberg, YH An - Pharmacological research, 2004 - Elsevier
The use of the new selective cyclooxygenase-2 (COX-2) inhibitors (such as celecoxib and
rofecoxib) for the treatment of pain and inflammation caused by fractures, cementless total …

The mechanisms of the inhibitory effects of nonsteroidal anti‐inflammatory drugs on bone healing: a concise review

AT Harder, YH An - The Journal of Clinical Pharmacology, 2003 - Wiley Online Library
Nonsteroidal anti‐inflammatory drug (NSAID) use continues to expand at a remarkable rate
due both to the broad spectrum of clinical applications for these medications and to the …

Non‐steroidal anti‐inflammatory drugs, cyclooxygenase‐2 and the bone healing process

K Vuolteenaho, T Moilanen… - Basic & clinical …, 2008 - Wiley Online Library
Traditional non‐steroidal anti‐inflammatory drugs (NSAID) and selective cyclooxygenase‐2
(COX‐2) inhibitors are widely used in the treatment of pain, including bone fracture pain and …

Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro

M Kellinsalmi, V Parikka, J Risteli, T Hentunen… - European journal of …, 2007 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenases (COX) and are
widely used for post-trauma musculoskeletal analgesia. In animal models, NSAIDs have …

The effect of nonsteroidal anti-inflammatory drugs on tissue healing

MR Chen, JL Dragoo - Knee Surgery, Sports Traumatology, Arthroscopy, 2013 - Springer
Abstract Purpose Non-selective (NSAIDs) and selective (COX-2) nonsteroidal anti-
inflammatory drugs are commonly used for their analgesic and anti-inflammatory effects …

Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

B Lisowska, D Kosson, K Domaracka - Drug design, development …, 2018 - Taylor & Francis
Tissue damage following injury triggers the processes of coagulation, inflammation and
healing. In tissues surrounding the bone, the result of the healing process is a scar, while …

The effect of cyclooxygenase-2 inhibitors on bone healing

NM Gajraj - Regional anesthesia and pain medicine, 2003 - search.proquest.com
Cyclooxygenase (COX) catalyzes the initial step of arachidonic acid metabolism and
prostaglandin production. COX activity has been found to be associated with 2 distinct …

Effects of cyclooxygenase inhibition on bone, tendon, and ligament healing

ZA Radi, NK Khan - Inflammation Research, 2005 - Springer
Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to
prostaglandins (PGs). PGs play a significant role in bone metabolism in health and disease …