Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …

Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The first broad-
spectrum multicomponent vaccine against serogroup B meningococcus (MenB), 4CMenB …

Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …

Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with
high factor H binding protein (FHbp) expression that were resistant to complement-mediated …

Neisseria meningitidis remains a leading cause of bacterial sepsis and meningitis.
Complement is a key component of natural immunity against this important human …

Complement forms an important arm of innate immunity against invasive meningococcal
infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding …

Factor H-binding protein (fHBP; GNA1870) is one of the antigens of the recombinant vaccine
against serogroup B Neisseria meningitidis, which has been developed using reverse …

A bivalent factor H binding protein (fHBP) vaccine for the prevention of disease caused by
Neisseria meningitidis serogroup B is currently in clinical development. Since fHBP is also …

Binding of the complement inhibitor factor H (fH) to the surface of Neisseria meningitidis is
critical for evasion of innate host defenses. The meningococcal vaccine candidate factor H …

GNA1870, also named factor H-binding protein (fHbp) or rLP-2086, is a genome-derived
antigen and one of the components of a rationally designed vaccine against Neisseria …