The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4+
FOXP3+ regulatory T (Treg) cells. Human Treg cells express several different isoforms of …

Foxp3 is responsible for the major immunological features of Treg cells, including
hypoproliferation in vitro, immune suppression of conventional T cells and resistance to Th2 …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

Background The forkhead box transcription factor, Foxp3, is master regulator of the
development and function of CD4+ CD25+ T regulatory (Treg) cells that limit autoimmunity …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Regulatory T cells (Tregs) are a specialized subset of CD4+ T cells essential for the
maintenance of immune homeostasis and prevention of autoimmunity. Treg lineage and …

The immune system is responsible for not only eliminating threats to the body, but also for
protecting the body from its own immune responses that would cause harm if left unchecked …

Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3
encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) …

CD4+ regulatory T cells (Treg cells) characterized by expression of the transcription factor
Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice …

Regulatory T (Treg) cells constitute a unique T-cell lineage that plays a pivotal role in the
maintenance of the peripheral tolerance. The transcription factor Foxp3 (Forkhead box P3) …