Although initially purified from platelets,'two distinct forms of TGFP have been purified from
bone. In fact, the second form, TGFP-I1 was identified initially in bone.'.'These two bone …

Transforming growth factor-beta (TGF-β) plays a critical role in bone remodeling. TGF-β
stimulates matrix protein synthesis, has dramatic effects on the bone cells responsible for …

At first reading the statement “TGFβ stimulates bone formation but inhibits mineralization”
may appear to be an oxymoron. However, the bone formation process can take weeks to …

Bone formation results from the anabolic and catabolic functions of osteoblasts and
osteoclasts within bone. The activities of these cell populations are controlled by complex …

Normal skeletal growth results from a balance between the processes of bone matrix
synthesis and resorption. These activities are regulated by both systemic and local factors …

The integrity of the skeleton is maintained by the continuous remodeling of the calcified
matrix by the activity of bone cells. Bone remodeling occurs throughout the skeleton in …

Two related proteins, cartilage-inducing factors A and B (CIF-A and CIF-B), which promote
expression of the chondrocyte phenotype in rat fetal mesenchymal cells were isolated from …

Publisher Summary This chapter focuses on Transforming Growth Factor-β (TGF β). TGFβl is
the prototype and the founding molecule for the TGFβ superfamily. This family has grown to …

The integrity of the skeleton is maintained by the continued cellular remodelling of bone that
occurs throughout life and is characterized by an orderly sequence of events beginning with …

EARLY efforts to purify a bone-derived growth factor from rat bone culture medium revealed
its biological and biochemical similarity to transforming growth factor-β type 1 (TGF-β1) …