Mitochondria are double-membraned highly dynamic organelles; the shape, location and
function of which are determined by a constant balance between opposing fusion and …

Abstract “Friends come and go but enemies accumulate.”—Arthur Bloch Mitochondrial
networks in eukaryotic cells are maintained via regular cycles of degradation and …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying
mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle …

Mitochondria are the powerhouses for the cell, consuming oxygen to generate sufficient
energy for the maintenance of normal cellular processes. However, a deleterious …

Mitochondria are critical organelles in energy conversion, metabolism and amplification of
signalling. They are however also major sources of reactive oxygen species and when …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mitochondria are the energy producing dynamic double-membraned organelles essential
for cellular and organismal survival. A multitude of intra-and extra-cellular signals involved in …

Cellular degradative processes including proteasomal and vacuolar/lysosomal (autophagic)
degradation, as well as the activity of proteases (both cytosolic and mitochondrial), provide …