The high antioxidative power of quercetin (aglycone flavonoid) and its glycone (rutin) avert high cholesterol diet induced hepatotoxicity and inflammation in Swiss …

K Sikder, SB Kesh, N Das, K Manna, S Dey - Food & Function, 2014 - pubs.rsc.org
The present study demonstrates for the first time the protective role of two common
flavonoids, quercetin and its glycone rutin, against high cholesterol diet (2%) induced …

Quercetin and β-sitosterol prevent high fat diet induced dyslipidemia and hepatotoxicity in Swiss albino mice

K Sikder, N Das, SB Kesh, S Dey - 2014 - nopr.niscpr.res.in
High fat diet group showed a significant rise in serum and hepatic total cholesterol,
triglyceride and atherogenic index which are major biomarkers of dyslipidemia and …

Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

AD Mariee, GM Abd-Allah… - Pharmaceutical …, 2012 - Taylor & Francis
Context: Quercetin, a dietary-derived flavonoid, is ubiquitous in fruits and vegetables and
plays important roles in human health by virtue of its antioxidant activity. Objective: This …

Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats

SH Bok, SY Park, YB Park, MK Lee… - … journal for vitamin …, 2002 - econtent.hogrefe.com
This study was designed to test the lipid-lowering and antioxidant activity of two
bioflavonoids, quercetin dihydrate and gallate. Four groups of rats were given a …

Comparison of antioxidant and anti‐inflammatory activity of quercetin, isoquercitrin and rutin against alcohol‐induced liver injury in HepG2 Cells

J Song, Y Kim, J Lee - The FASEB Journal, 2018 - Wiley Online Library
The dietary flavonoids and their glycosides are the most vital phytochemicals in diets and
are of great general interest due to their diverse bioactivities. The natural flavonoids almost …

Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells

S Vidyashankar, RS Varma, PS Patki - Toxicology in Vitro, 2013 - Elsevier
Hepatic lipid accumulation and oxidative stress contribute to non-alcoholic fatty liver disease
(NAFLD). Thus, we hypothesized that the hypolipidemic and antioxidant activity of quercetin …

[PDF][PDF] Ameliorative effects of rutin and ascorbic acid combination on hypercholesterolemia-induced hepatotoxicity in female rats

AM Aleisa, HM Abouhashish… - Afr. J. Pharm …, 2013 - academicjournals.org
It has been shown that female rats are more responsive to dietary cholesterol challenge than
male and also, hypercholesterolemia induction is easier in female rats. The present study …

Rutin attenuates hepatotoxicity in high‐cholesterol‐diet‐fed rats

SD AlSharari, SS Al-Rejaie… - Oxidative Medicine …, 2016 - Wiley Online Library
Background and Objective. High‐cholesterol diet (HCD) intends to increase the oxidative
stress in liver tissues inducing hepatotoxicity. Rutin is a natural flavonoid (vitamin p) which is …

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

HZ Ying, YH Liu, B Yu, ZY Wang, JN Zang… - Food and Chemical …, 2013 - Elsevier
Dietary quercetin is highly abundant in edible plants, which possesses a wide range of
pharmacological properties. This study was to investigate hepatoprotective effects of …

Dietary quercetin supplementation increases serum antioxidant capacity and alters hepatic gene expression profile in rats

L Zhao, J Wu, J Yang, J Wei… - … Biology and Medicine, 2011 - journals.sagepub.com
The aim of this study was to determine the effect of quercetin on hepatic gene expression
profile in rats. Twenty male Wistar rats were divided into the control group and the quercetin …