Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

Sickle cell disorders, such as Hb SS and Hb SC, are associated with a hypercoagulable
state that may contribute to the vaso‐occlusive episodes observed in the disorders. To what …

Recent epidemiologic data suggest that sickle cell trait (Hb AS; AS) is a risk factor for venous
thromboembolism. We conducted an exploratory study of healthy subjects with AS under …

Abnormalities of coagulation and fibrinolysis were studied in a group of 28 children and
young adults with homozygous sickle cell disease (SCD), either in the steady state (n= 12) …

In the present study we examined if, among other mechanisms, the abnormal exposure of
phosphatidylserine at the surface of sickle red blood cells (RBCs) contributes to the …

Although the mechanisms involved in the persistent clinical complications of sickle cell
disease have not yet been fully delineated, previous studies suggest that sickle cell (HbSS) …

Essentials• Sickle cell disease is increasingly being recognized as a chronic
hypercoagulable state.• Thrombin generation is elevated in the whole blood, but not the …

Coagulation studies were carried out in 117 Jamaicans with homo‐zygous sickle‐cell
disease in the steady state, and 40 local controls. The patients had significantly higher factor …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Proteins C and S are vitamin K-dependent proteins with an essential anticoagulant function.
Protein C exists in an inactive form and is activated by a thrombin-thrombomodulin complex …