Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week …

S Homsi, T Piaggio, N Croci, F Noble… - Journal of …, 2010 - liebertpub.com
Traumatic brain injury (TBI) causes a wide spectrum of consequences, such as microglial
activation, cerebral inflammation, and focal and diffuse brain injury, as well as functional …

Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or …

N Bye, MD Habgood, JK Callaway, N Malakooti… - Experimental …, 2007 - Elsevier
Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice

SY Ng, BD Semple, MC Morganti-Kossmann… - Journal of …, 2012 - liebertpub.com
Neurogenesis is stimulated following injury to the adult brain and could potentially contribute
to tissue repair. However, evidence suggests that microglia activated in response to injury …

Minocycline transiently reduces microglia/macrophage activation but exacerbates cognitive deficits following repetitive traumatic brain injury in the neonatal rat

LA Hanlon, JW Huh… - Journal of Neuropathology …, 2016 - academic.oup.com
Elevated microglial/macrophage-associated biomarkers in the cerebrospinal fluid of infant
victims of abusive head trauma (AHT) suggest that these cells play a role in the …

Minocycline plus N-acetylcysteine reduce behavioral deficits and improve histology with a clinically useful time window

MA Sangobowale, NM Grin'kina, K Whitney… - Journal of …, 2018 - liebertpub.com
There are no drugs to manage traumatic brain injury (TBI) presently. A major problem in
developing therapeutics is that drugs to manage TBI lack sufficient potency when dosed …

Differential effects of minocycline on microglial activation and neurodegeneration following closed head injury in the neonate rat

LA Hanlon, R Raghupathi, JW Huh - Experimental neurology, 2017 - Elsevier
The role of microglia in the pathophysiology of injury to the developing brain has been
extensively studied. In children under the age of 4 who have sustained a traumatic brain …

Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration

G Scott, H Zetterberg, A Jolly, JH Cole, S De Simoni… - Brain, 2018 - academic.oup.com
Survivors of a traumatic brain injury can deteriorate years later, developing brain atrophy
and dementia. Traumatic brain injury triggers chronic microglial activation, but it is unclear …

Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1–inhibiting mechanism

K Hayakawa, K Mishima, M Nozako, M Hazekawa… - Stroke, 2008 - Am Heart Assoc
Background and Purpose—Minocycline, a semisynthetic tetracycline antibiotic, has been
reported to ameliorate brain injury and inhibit microglial activation after focal cerebral …

Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury

M Celorrio, K Shumilov, C Payne, S Vadivelu… - Acta neuropathologica …, 2022 - Springer
Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy
for TBI have failed to replicate these results in humans, in part due to the absence of …

Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction

ROS Mejia, VO Ona, M Li, RM Friedlander - Neurosurgery, 2001 - journals.lww.com
OBJECTIVE Caspase-1 plays an important functional role mediating neuronal cell death
and dysfunction after experimental traumatic brain injury (TBI) in mice. Minocycline, a …