Sickle cell disease has been described by many scholars as a chronic inflammatory disease
which is linked to many factors such as endothelial destruction, increased synthesis of …

Acute painful crisis is a common sequela that can cause significant morbidity and negatively
impact the quality of life of patients with sickle cell disease (SCD). Plasma levels of several …

Sickle cell disease (SCD) is characterized by chronic hemolysis, frequent infections, and
recurrent occlusions of microcirculation, which cause painful crises and result in chronic …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

The role of inflammation cannot be over emphasized in the pathophysiology of Sickle cell
disease. Adhesive sickle reticulocytes initiate vaso occlusion Sickle cell disease is …

The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients
in steady state and in vaso‐occlusive crisis (VOC). VOC has a complex nature, involving …

Sickle red cells express adhesion molecules including integrin 4β1, CD36, band 3 protein,
sulfated glycolipid, Lutheran protein, phosphatidylserine and integrin-associated protein …

Sickle cell disease is the most common inherited haematological disorder that leads to the
irreversible damage of multiple organs. Although sickling of red blood cells and vaso …

The pathogenesis of sickle vaso-occlusive crisis (VOC) in sickle cell disease (SCD) patients
involves the accumulation of rigid sickle cells and the stimulation of an ongoing inflammatory …