Higher-Order Structures of Chromatin: The Elusive 30 nm Fiber: Cell Skip to Main Content
Advertisement Cell This journal offers authors two options (open access or subscription) to …

Despite over 30years of work, the fundamental structure of eukaryotic chromatin remains
controversial. Here, we review the roots of this controversy in disparities between results …

Chromatin structure plays a fundamental role in the regulation of nuclear processes such as
DNA transcription, replication, recombination, and repair. Despite considerable efforts …

The structure of the '30nm'chromatin fibre has eluded us for 30 years and remains a major
unsolved problem in biology. Progress during the past year has led to the proposal of two …

Eukaryotic genomes must be folded and compacted to fit within the restricted volume of the
nucleus. According to the current paradigm, strings of nucleosomes, termed 10nm chromatin …

Eukaryotic genomes are organized hierarchically into chromatin structures by histones.
Despite extensive research for over 30 years, not only the fundamental structure of the 30 …

Chromatin adopts a diversity of regular and irregular fiber structures in vitro and in vivo.
However, how an array of nucleosomes folds into and switches between different fiber …

Chromatin fiber organization is implicated in processes such as transcription, DNA repair
and chromosome segregation, but how nucleosomes interact to form higher-order structure …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …

The structure of the 30‐nm chromatin fibre is an important determinant of the regulation of
eukaryotic transcription. A fundamental issue is whether the stacking of nucleosomes in this …