Modulation of offset analgesia in patients with chronic pain and healthy subjects–a systematic review and meta-analysis

DB Larsen, XJ Uth, L Arendt-Nielsen… - … Journal of Pain, 2022 - degruyter.com
Objectives Offset analgesia (OA) induces a brief pain inhibition and studies suggest OA
impairment in patients with chronic pain when compared to healthy subjects. Conditioned …

An overview of offset analgesia and the comparison with conditioned pain modulation: a systematic literature review

L Hermans, P Calders, J Van Oosterwijck… - Pain …, 2016 - repository.uantwerpen.be
Background: Offset analgesia (OA) is an increasingly described phenomenon to measure
endogenous pain inhibition, in which a greater decrease in pain intensity is experienced …

The magnitude of offset analgesia as a measure of endogenous pain modulation in healthy participants and patients with chronic pain: A systematic review and meta …

TM Szikszay, WM Adamczyk… - The Clinical journal of …, 2019 - journals.lww.com
Objective: Offset analgesia (OA) is a test paradigm increasingly used to estimate
endogenous pain modulation characterized by a disproportionally profound analgesia after …

Attenuation of offset analgesia is associated with suppression of descending pain modulatory and reward systems in patients with chronic pain

S Zhang, T Li, H Kobinata, E Ikeda, T Ota… - Molecular …, 2018 - journals.sagepub.com
Background Offset analgesia is a disproportionate decrease of pain perception following a
slight decrease of noxious thermal stimulus and attenuated in patients with neuropathic …

The effect of acute‐experimental pain models on offset analgesia

TM Szikszay, WM Adamczyk, A Hoegner… - … Journal of Pain, 2021 - Wiley Online Library
Background Offset analgesia (OA) is characterized by a disproportionately large decrease in
pain perception after a slight decrease in noxious stimulation. In patients with ongoing pain …

Reproducibility of psychophysics and electroencephalography during offset analgesia

M Nilsson, A Piasco, TD Nissen… - … journal of Pain, 2014 - Wiley Online Library
Background Offset analgesia (OA) is a pain‐inhibiting mechanism, defined as a
disproportionately large decrease in pain perception in response to a discrete decrease in …

[HTML][HTML] Assessing the influence of non-ischaemic A-fiber conduction blockade on offset analgesia: an experimental study

L Luebke, CG Lopes, Y Myka, A Lumma… - The Journal of …, 2024 - Elsevier
Offset analgesia (OA) is believed to reflect the efficiency of the endogenous pain modulatory
system. However, the underlying mechanisms are still being debated. Previous research …

Disrupted offset analgesia distinguishes patients with chronic pain from healthy controls

H Kobinata, E Ikeda, S Zhang, T Li, K Makita, J Kurata - Pain, 2017 - journals.lww.com
Offset analgesia (OA) represents a disproportionately large decrease of pain perception
after a brief, temporary increment of thermal pain stimulus and was reported attenuated in …

Offset analgesia and the impact of treatment with oxycodone and venlafaxine: A placebo‐controlled, randomized trial in healthy volunteers

AE Olesen, TD Nissen, M Nilsson… - Basic & Clinical …, 2018 - Wiley Online Library
Offset analgesia (OA) is a pain‐modulating mechanism described as a disproportionately
large decrease in pain intensity evoked by a discrete decrease in stimulus temperature. The …

Offset analgesia is reduced on the palm and increases with stimulus duration

CL Asplund, A Kannangath, VJE Long… - … Journal of Pain, 2021 - Wiley Online Library
Background A noxious stimulus following a more intense stimulus often feels less painful
than continuous noxious stimulation. This effect, known as offset analgesia (OA), may be …