Stress is considered as an important risk factor in the progression and the onset of many
disorders such as multiple sclerosis. However, metabolite changes as a result of …

Non-invasive measures of well-known pathological hallmarks of multiple sclerosis (MS)
such as demyelination, inflammation and axonal injury would serve as useful markers to …

Multiple sclerosis (MS) is known as the most common demyelinating disease worldwide in
which previous studies have shown that stress is a risk factor for the disease's onset and …

Conventional MRI is frequently used during the diagnosis of multiple sclerosis but provides
only little additional pathological information. Proton MRS (1H‐MRS), however, provides …

This study quantitatively measured the changes in metabolites in the hippocampal lesions of
a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton …

Cuprizone (CPZ) is a copper chelating agent able to selectively insult mature
oligodendrocytes (OLs) in brains of rodents. The CPZ-exposed mice show behavioral …

The brain 3β-hydroxysteroid dehydrogenase (3β-HSD), is the enzyme that catalyzes the
biosynthesis of a neuroprotective factor, progesterone. The regulation of 3β-HSD in …

Cuprizone is a copper-chelating agent and able to induce oligodendrocyte loss and
demyelination in C57BL/6 mouse brain. Recent studies have used the cuprizone-fed mouse …

Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple
sclerosis in which oxidative stress has been documented as one of the cascade in the …

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS). Here we report the temporal and spatial evolution of …