Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Cytokine storm: the primary determinant for the pathophysiological evolution of COVID-19 deterioration

R Chen, Z Lan, J Ye, L Pang, Y Liu, W Wu… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global …

Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
Corona virus disease 2019 (COVID-19) has caused a global outbreak and severely posed
threat to people's health and social stability. Mounting evidence suggests that …

The meteorology of cytokine storms, and the clinical usefulness of this knowledge

IA Clark, B Vissel - Seminars in immunopathology, 2017 - Springer
The term cytokine storm has become a popular descriptor of the dramatic harmful
consequences of the rapid release of polypeptide mediators, or cytokines, that generate …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokine production …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

[HTML][HTML] Cytokine storms: understanding COVID-19

N Mangalmurti, CA Hunter - Immunity, 2020 - cell.com
The elevated circulating levels of cytokines associated with a variety of infectious and
immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the …

Immunomodulation and sepsis: impact of the pathogen

P Moine, E Abraham - Shock, 2004 - journals.lww.com
Infection begins when microorganisms overcome host barriers and multiply within host
tissues. To contain the infection, the host mounts an inflammatory response that mobilizes …