Over the past sixty years, researchers have made outmost efforts to clarify the structural
organization and functional regulation of the complexes that configure the mitochondrial …

The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for
ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused …

Respiratory chain dysfunction plays an important role in human disease and aging. It is now
well established that the individual respiratory complexes can be organized into …

Open questions: respiratory chain supercomplexes—why are they there and what do they do?
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The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

The protein complexes of the mitochondrial oxidative phosphorylation system were recently
reported to form supramolecular assemblies termed respiratory supercomplexes or …

The structural organization of the mitochondrial oxidative phosphorylation (OXPHOS)
system has received large attention in the past and most investigations led to the conclusion …

In the inner mitochondrial membrane, the respiratory chain complexes generate an
electrochemical proton gradient, which is utilized to synthesize most of the cellular ATP …

The mitochondrial respiratory chain (MRC) is comprised of~ 92 nuclear and mitochondrial
DNA-encoded protein subunits that are organized into five different multi-subunit respiratory …

Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins
and cofactors of the electron transport chain. The initial idea that the respiratory chain …