Pharmacological agents and impairment of fracture healing: what is the evidence?

I Pountos, T Georgouli, TJ Blokhuis, HC Pape… - Injury, 2008 - Elsevier
Bone healing is an extremely complex process which depends on the coordinated action of
several cell lineages on a cascade of biological events, and has always been a major …

Drugs for bone healing

ML Brandi - Expert opinion on investigational drugs, 2012 - Taylor & Francis
Introduction: The biological process of fracture healing is complex with influences that are
both patient-dependent and related to the trauma experienced and stability of the fracture …

Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

B Lisowska, D Kosson, K Domaracka - Drug design, development …, 2018 - Taylor & Francis
Tissue damage following injury triggers the processes of coagulation, inflammation and
healing. In tissues surrounding the bone, the result of the healing process is a scar, while …

Fracture repair: general aspects and influence of osteoporosis and anti-osteoporosis treatment

JM Féron, R Mauprivez - Injury, 2016 - Elsevier
Bone differs from other tissues in its capacity to self-repair after a fracture. The low bone
mass and structural deterioration of bone associated with osteoporosis increases the risk of …

The mechanisms of the inhibitory effects of nonsteroidal anti‐inflammatory drugs on bone healing: a concise review

AT Harder, YH An - The Journal of Clinical Pharmacology, 2003 - Wiley Online Library
Nonsteroidal anti‐inflammatory drug (NSAID) use continues to expand at a remarkable rate
due both to the broad spectrum of clinical applications for these medications and to the …

Effects of anti-osteoporosis medications on fracture healing

NR Jørgensen, P Schwarz - Current osteoporosis reports, 2011 - Springer
A number of fractures are complicated by impaired healing. This is prevalent in certain risk
groups such as elderly, osteoporotics, postmenopausal women, and in people with …

Do nonsteroidal anti‐inflammatory drugs affect bone healing? A critical analysis

I Pountos, T Georgouli, GM Calori… - The Scientific World …, 2012 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) play an essential part in our approach to
control pain in the posttraumatic setting. Over the last decades, several studies suggested …

Effect of osteoporosis medications on fracture healing

V Hegde, JE Jo, P Andreopoulou, JM Lane - Osteoporosis International, 2016 - Springer
Antiosteoporotic medications are often used to concurrently treat a patient's fragility fractures
and underlying osteoporosis. This review evaluates the existing literature from animal and …

Mechanisms underlying normal fracture healing and risk factors for delayed healing

C Cheng, D Shoback - Current Osteoporosis Reports, 2019 - Springer
Abstract Purpose of Review Substantial advances have been made in understanding the
biological basis of fracture healing. Yet, it is unclear whether the presence of osteoporosis or …

Effects of nonsteroidal anti-inflammatory drugs on bone formation and soft-tissue healing

LE Dahners, BH Mullis - … -Journal of the American Academy of …, 2004 - journals.lww.com
Nonsteroidal anti-inflammatory drugs continue to be prescribed as analgesics for patients
with healing fractures even though these drugs diminish bone formation, healing, and …