The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

The underlying causes of most mood and anxiety disorders remain unknown. There is a
strong heritable component to psychiatric illnesses that, when coupled with environmental …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

BACKGROUND Research on the neurobiology of depression began in earnest in the late
1950s, when converging lines of evidence pointed to the possibility of dysfunction of CNS …

Depression is a common and debilitating mental health condition whose underlying
aetiology and pathophysiology is still relatively poorly understood. In this article, we first turn …

Depression is a common and devastating neuropsychiatric disorder, and a better
understanding of its pathophysiology is needed to improve diagnosis, treatment and …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Objective To review the current evidence about the neurobiological mechanisms in major
depressive disorders (MDD) and the key findings from studies using neuroimaging tools and …