Introduction In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are
characteristically deformed and inflexible. Often breaking down in the circulation, they …

Sickle cell disease (SCD) is a hereditary disorder that leads to the production of an
abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions …

Background: Sickle Cell Disease (SCD) describes a group of inherited hemolytic disorders
caused by structurally abnormal variants of hemoglobin, which result in the sickle-shaped …

Despite a long history of knowing the genetic cause of sickle cell disease (SCD), progress in
developing treatments to prevent painful vaso-occlusive crises and the other myriad of …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin
gene HBB leading to polymerization of red blood cells causing damage to cell membranes …

Sickle cell disease (SCD) is an hereditary disorder characterized by the production of an
abnormal hemoglobin called hemoglobin S (HbS). HbS may polymerize in deoxygenated …

Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …