Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …

In the present study, we tested whether the ongoing differentiation of microglia in the
immature brain results in more robust microglial activation and pro-inflammatory responses …

Background: Perinatal asphyxia, leading to neonatal encephalopathy, is one of the leading
causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are …

We previously found increased microglial proliferation and pro-inflammatory cytokine
release in infant mice compared to juvenile mice after hypoxia–ischemia (HI). The aim of the …

Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …

Background Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of
brain injury in preterm infants. Preterm HIE is predominantly caused by global hypoxia …

Inflammation plays a critical role in mediating brain injury induced by neonatal hypoxic
ischemic encephalopathy (HIE). The mechanisms underlying inflammatory responses to …

Background Hypoxia-ischemia (HI) can produce widespread neurodegeneration and deep
cerebral white matter injury in the neonate. Resident microglia and invading leukocytes …

The mechanisms of neuronal injury after hypoxia–ischemia (HI) are different in the immature
and the adult brain, but microglia activation has not been compared. The purpose of this …

Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …