Abstract Interleukin-1 receptor-associated kinases (IRAKs), particularly IRAK1 and IRAK4,
are important in transducing signal from Toll-like receptor 4. We interrogated if a selective …

Interleukin-1 receptor–associated kinase 4 (IRAK-4) was reported to be essential for the Toll-
like receptor (TLR)–and T cell receptor (TCR)–mediated signaling leading to the activation …

IRAK4 is a member of IL-1 receptor (IL-1R)–associated kinase (IRAK) family and has been
shown to play an essential role in Toll-like receptor (TLR)–mediated signaling. We recently …

Sepsis is the leading cause of mortality in intensive care units due to complex inflammatory
immune responses and immunosuppression. Recent studies have indicated that the …

Increasing evidence supports vanillin and its analogs as potent toll-like receptor signaling
inhibitors that strongly attenuate inflammation, though, the underlying molecular mechanism …

Abstract IRAK‐4 kinase inactive (IRAK‐4 KD) knock‐in mice display defects in TLR‐and IL‐1
receptor signaling and are resistant to LPS‐induced shock. In the present study we …

A member of the IL‐1 receptor (IL‐1R)‐associated kinase (IRAK) family, IRAK4, has been
shown to play an essential role in Toll‐like receptor (TLR)‐mediated signaling. IRAK4 …

IRAK2, a member of the interleukin-1 receptor-associated kinase (IRAK) family, has been
implicated in Toll-like receptor (TLR)-mediated signaling. We generated IRAK2-deficient …

The generation of reactive oxygen species (ROS) triggered by bacterial endotoxin
lipopolysaccharide (LPS) plays a key role during the pathogenesis of sepsis. Given the key …

Background Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …