Normal pituitary and gonadal function can be maintained with long term pulsatile GnRH
administration in men with idiopathic hypogonadotropic hypogonadism (IHH), and both …

The effects of increasing the frequency of pulsatile GnRH administration on LH and FSH
responsiveness were studied in five GnRH-deficient men who had achieved normal sex …

Although pharmacological doses of GnRH and TRH stimulate free α-subunit (α-subunit)
secretion from the pituitary, little is known about the pattern and control of asubunit release …

Idiopathic isolated gonadotropin deficiency (IGD) is associated with a spectrum of clinical
findings as well as variable gonadotropin responses to GnRH. In this study we investigated …

To determine the role of testosterone (T) in modulating gonadotropin secretion during sexual
maturation, we studied males with isolated gonadotropin deficiency (IGD) before and during …

Several lines of evidence indicate that hypothalamic-pituitary-gonadal activity varies among
men with idiopathic hypogonadotropic hypogonadism (IHH). To test the hypothesis that a …

GnRH pulse frequency, amplitude, and interpulse interval have all been demonstrated to
regulate gonadotropin secretion individually. We tested the hypothesis that the contour of …

Previous investigations of the effects of GnRH on pituitary LH responses in normal men
required pharmacological doses of GnRH to avoid the confounding effects of endogenous …

H YPOGONADOTROPIC hypogonadism (HH) is a clinical syndrome occurring in both sexes
which has long puzzled clinicians due to the apparent paradox of nonfunctioning gonads in …

Patients with isolated gonadotropin deficiency were studied to determine whether pulsatile
low dose gonadotropin-releasing hormone (GnRH) could induce the hormonal changes …