Electrical detection of cancer biomarker using aptamers with nanogap break-junctions

A Ilyas, W Asghar, PB Allen, H Duhon… - …, 2012 - iopscience.iop.org
Epidermal growth factor receptor (EGFR) is a cell surface protein overexpressed in
cancerous cells. It is known to be the most common oncogene. EGFR concentration also …

A “signal-on” electrochemical aptasensor for simultaneous detection of two tumor markers

J Zhao, X He, B Bo, X Liu, Y Yin, G Li - Biosensors and Bioelectronics, 2012 - Elsevier
In this paper, we report a “signal-on” electrochemical aptasensor for simultaneous
determination of two tumor markers MUC1 and VEGF165, by using a ferrocene-labeled …

Electrochemical aptasensors for early cancer diagnosis: a review

M Oguzhan Caglayan - Current Analytical Chemistry, 2017 - ingentaconnect.com
Aptamers are specific oligonucleotides selected invitro which bind to target molecules with
high affinity and specificity like antibody-antigen interactions. For that reason, these synthetic …

Aptamer-based nanobiosensors

YS Kim, NHA Raston, MB Gu - Biosensors and Bioelectronics, 2016 - Elsevier
It has been more than two decades since aptamer and the systematic evolution of ligands by
exponential enrichment (SELEX) method were discovered by Larry Gold and Andrew …

Aptamers as molecular recognition elements for electrical nanobiosensors

JO Lee, HM So, EK Jeon, H Chang, K Won… - Analytical and …, 2008 - Springer
Recent advances in nanotechnology have enabled the development of nanoscale sensors
that outperform conventional biosensors. This review summarizes the nanoscale biosensors …

Synergizing nucleic acid aptamers with 1-dimensional nanostructures as label-free field-effect transistor biosensors

YL Khung, D Narducci - Biosensors and Bioelectronics, 2013 - Elsevier
Since the introduction by Gold et al. in 1990, nucleic acid aptamers had evolved to become
a true contender in biosensors for protein and cell detections. Aptamers are short strands of …

Cancer Diagnostics and early detection using Electrochemical Aptasensors

JI Omage, E Easterday, JT Rumph, I Brula, B Hill… - Micromachines, 2022 - mdpi.com
The detection of early-stage cancer offers patients the best chance of treatment and could
help reduce cancer mortality rates. However, cancer cells or biomarkers are present in …

A hairpin DNA aptamer coupled with groove binders as a smart switch for a field-effect transistor biosensor

T Goda, Y Miyahara - Biosensors and Bioelectronics, 2012 - Elsevier
We report here that a hairpin-structured DNA that possesses an anti-ATP aptamer sequence
successfully detected target ATP or adenosine in a temperature-dependent manner by …

Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring

J Wang, D Chen, W Huang, N Yang, Q Yuan… - …, 2023 - Wiley Online Library
Nano‐biosensors that are composed of recognition molecules and nanomaterials have
been extensively utilized in disease diagnosis, health management, and environmental …

Electrochemical aptamer biosensor for DNA detection based on label-free aptamers

L Li, Z Chen - Bioelectrochemistry, 2023 - Elsevier
Electrochemical aptasensor has been broadly advanced for nucleic acid detection.
However, it is a long-term goal to design an aptasensor with high specificity, flexibility, and …