Modelling of C-terminal tail of human STING and its interaction with tank-binding kinase 1.

R Ata Ouda Al-Masri, H Audu-Bida… - Turkish Journal of …, 2022 - search.ebscohost.com
Stimulator of interferon genes (STING) plays a significant role in a cell's intracellular defense
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway …

Modeling of C-terminal tail of human STING and its interaction with tank-binding kinase 1

RAO Al-Masri, H Audu-Bida… - Turkish Journal of …, 2022 - journals.tubitak.gov.tr
Stimulator of interferon genes (STING) plays a significant role in a cell's intracellular defense
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway …

Unraveling the molecular details of the innate immune response

J Fernández-Recio - EBioMedicine, 2016 - thelancet.com
There is increasing evidence of the important role of innate immune system in tumor
surveillance (Vesely et al., 2011). The spontaneous immune response of T cells against …

Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding

S Ouyang, X Song, Y Wang, H Ru, N Shaw, Y Jiang… - Immunity, 2012 - cell.com
STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-mediated
type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and interferon …

Kinase activity of TBK1 is required for its binding to STING, but not for its recruitment to the Golgi

H Kemmoku, Y Kuchitsu, K Mukai, T Taguchi - bioRxiv, 2021 - biorxiv.org
Stimulator of interferon genes (STING) is an innate immune protein for DNA pathogens. In
response to the emergence of DNA in the cytosol, STING relocates from the endoplasmic …

The Many Ways to Deal with STING

C Coderch, J Arranz-Herrero, E Nistal-Villan… - International Journal of …, 2023 - mdpi.com
The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of
IFN-β and many other genes associated with the immune response activation in vertebrates …

Ligand-induced ordering of the C-terminal tail primes STING for phosphorylation by TBK1

Y Tsuchiya, N Jounai, F Takeshita, KJ Ishii… - …, 2016 - thelancet.com
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of
interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by …

Research Progress in the Mechanism of Functional Regulation of STING

J Wang, Q Zhao, G Li, L Zhou, L Hei… - Frontiers in Medical …, 2024 - francis-press.com
Interferon type I (IFN-I) plays a key role in intrinsic immunity against viruses and its
production is associated with the recognition of intracytoplasmic non-self DNA by the cyclic …

[HTML][HTML] Structural and Functional Analysis of STING Sheds New Light on Cyclic di-GMP Mediated Immune Signaling Mechanism

S Ouyang, X Song, Y Wang, H Ru, N Shaw, Y Jiang… - Immunity, 2012 - ncbi.nlm.nih.gov
SUMMARY STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-
mediated type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and Interferon …

Loops mediate agonist-induced activation of the stimulator of interferon genes protein

R Li, L Chen, X He, D Cao, Z Zhang… - Journal of Chemical …, 2023 - ACS Publications
The stimulator of interferon genes (STING) is an important therapeutic target for cancer
diseases. The activated STING recruits downstream tank-binding kinase 1 (TBK1) to trigger …