Proper vascular formation is regulated by multiple signaling pathways. The vascular
endothelial growth factor (VEGF) signaling promotes endothelial proliferation. Notch and its …

Rationale Proper functionality of the circulatory system requires correct arteriovenous (AV)
endothelial cell (EC) differentiation. While Notch signaling and its downstream effector Hes …

Proper arterial versus venous endothelial lineage identity is required to establish a
hierarchical network of arteries and veins and prevent the occurrence of life-threatening …

Rationale: Understanding the mechanisms that regulate arterial flow recovery is important to
design treatment options for peripheral artery disease patients ineligible for invasive …

Peripheral artery disease (PAD) is a significant global medical problem, affecting≈ 200
million people, including> 8 million Americans, especially in the aging population. 1 PAD …

Angiogenesis plays crucial roles in maintaining the complex operation of central nervous
system (CNS) development. The architecture of communication between neurogenesis and …

Members of the PRDM protein family have been shown to play important roles during
embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 …

Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening
complications occur, predominantly involving aortic rupture. Currently, no drug-based …

Peroxiredoxin 2 (PRDX2), an inhibitor of reactive oxygen species (ROS), is potentially
involved in the progression of atherosclerosis (AS). The aim of this study was to explore the …

Vegf signaling specifies arterial fate during early vascular development by inducing the
transcription of Delta-like 4 (Dll4), the earliest Notch ligand gene expressed in arterial …