The institution of methad one maintenance as a treatment modality for heroin addiction in
the mid-1960s was part of the growing medicalization of social problems in the United …

In 1965, Dole and Nyswander published the results of their initial experiences with using the
drug methadone as a maintenance treatment for chronic heroin addicts [1]. The results were …

In an era of renewed public apprehension about the spread of drug abuse in the United
States, it is meaningful to review basic issues pertaining to the effectiveness of treatment for …

Legislators, journalists and concerned citizens in general, when consider ing what to do
about the plague of heroin addiction in large cities, ask an obvious question:" Is methadone …

It is by now well understood in medicine that narcotic maintenance using methadone offers a
powerful tool for reducing the harms of opiate addiction and the array of public health and …

Extensive evaluation studies show that methadone maintenance therapy (MMT) reduces
heroin use and associated problems in a cost-effective manner, without negative public …

After thirty years of experience the essential questions concerning efficacy and safety of
methadone have been decisively answered. Dozens of independent studies, conducted by …

It is ten years since Vincent Dole and Marie Nvswander'first reported on their experience
with oral methadone as a maintenance treatment for heroin addiction. This is, then, an …

I have been asked to prepare a critical commentary on the Second National Conference on
Methadone Treatment. This conference included a variety of presentations, the largest …

Since first developed by Dole and Nyswander, there have been significant changes in the
clinical use of methadone, based on evaluation of the initial programs and a better …