Recent epidemiologic data suggest that sickle cell trait (Hb AS; AS) is a risk factor for venous
thromboembolism. We conducted an exploratory study of healthy subjects with AS under …

Sickle cell disorders, such as Hb SS and Hb SC, are associated with a hypercoagulable
state that may contribute to the vaso‐occlusive episodes observed in the disorders. To what …

People with sickle cell disease have a chronically activated coagulation system and display
hemostatic perturbations, but it is unknown whether they experience an increased risk of …

Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

The prothrombotic nature of sickle cell disease (SCD) is evidenced by the chronically
elevated levels of almost all coagulation activation biomarkers, and an increased incidence …

In the present study we examined if, among other mechanisms, the abnormal exposure of
phosphatidylserine at the surface of sickle red blood cells (RBCs) contributes to the …

Patients with sickle cell trait (STr) are usually considered to be asymptomatic. However,
complications, including hypercoagulability, increased risk of venous thromboembolism and …

Essentials• Sickle cell disease is increasingly being recognized as a chronic
hypercoagulable state.• Thrombin generation is elevated in the whole blood, but not the …

Recent studies suggest that intravascular coagulation occurs in sickle cell anemia. There is
also some evidence that decreased fibrinolytic activity may be associated with the disorder …

Although the mechanisms involved in the persistent clinical complications of sickle cell
disease have not yet been fully delineated, previous studies suggest that sickle cell (HbSS) …