Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques
To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines
capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that …
capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that …
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
Broad neutralization of SARS-related viruses by human monoclonal antibodies
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs)
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …
A broad and potent neutralization epitope in SARS-related coronaviruses
Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
Pan-sarbecovirus neutralizing antibodies in BNT162b2-immunized SARS-CoV-1 survivors
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of
concern pose a challenge to the effectiveness of current vaccines. A vaccine that could …
concern pose a challenge to the effectiveness of current vaccines. A vaccine that could …
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing
antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike …
antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike …