Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Neuroticism is an important risk factor for psychiatric traits, including depression, anxiety,,
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Neuroticism is a relatively stable personality trait characterized by negative emotionality (for
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …
Item-level analyses reveal genetic heterogeneity in neuroticism
Genome-wide association studies (GWAS) of psychological traits are generally conducted
on (dichotomized) sums of items or symptoms (eg, case-control status), and not on the …
on (dichotomized) sums of items or symptoms (eg, case-control status), and not on the …
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
EJCG van den Oord, PH Kuo… - Archives of general …, 2008 - jamanetwork.com
Context Neuroticism is a trait that reflects a tendency toward negative mood states. It has
long been linked to internalizing psychiatric conditions, such as anxiety and depression, and …
long been linked to internalizing psychiatric conditions, such as anxiety and depression, and …
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Neuroticism is a personality trait of fundamental importance for psychological well-being and
public health. It is strongly associated with major depressive disorder (MDD) and several …
public health. It is strongly associated with major depressive disorder (MDD) and several …
A genome-wide association study of neuroticism in a population-based sample
Neuroticism is a moderately heritable personality trait considered to be a risk factor for
developing major depression, anxiety disorders and dementia. We performed a genome …
developing major depression, anxiety disorders and dementia. We performed a genome …
Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder
Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …
Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life
Higher scores on the personality trait of neuroticism, the tendency to experience negative
emotions, are associated with worse mental and physical health. Studies examining links …
emotions, are associated with worse mental and physical health. Studies examining links …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …
because of limitations on sample size in previous studies. Subjective well-being, a …
Causal influences of neuroticism on mental health and cardiovascular disease
F Zhang, A Baranova, C Zhou, H Cao, J Chen, X Zhang… - Human genetics, 2021 - Springer
We investigated the relationship between neuroticism and 16 mental and 18 physical traits
using summary results of genome-wide association studies for these traits. LD score …
using summary results of genome-wide association studies for these traits. LD score …